Diagnosis and treatment of immune-mediated heparin-induced thrombocytopenia

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منابع مشابه

Heparin induced thrombocytopenia

Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...

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New developments in diagnosis and treatment of heparin-induced thrombocytopenia.

Heparin-induced thrombocytopenia (HIT) is a drug induced immune mediated thrombocytopenia that affects up to 3% of patients treated with unfractionated heparin (UFH). It is less frequent when low molecular weight heparins (LMWH) are used. Fondaparinux does not seem to induce HIT. A functional and an antigen assay should be performed to confirm the clinical diagnosis of HIT. Immediate cessation ...

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Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment.

Heparin induced thrombocytopenia thrombosis (HIT/T) is associated with a high morbidity and mortality. Diagnosis is essentially clinical and negative results of laboratory assays do not exclude the diagnosis. Treatment involves stopping all heparin immediately and giving an alternative thrombin inhibitor. The adoption of low molecular weight heparins is one reason for the reduced incidence of t...

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ژورنال

عنوان ژورنال: Nihon Shuchu Chiryo Igakukai zasshi

سال: 2008

ISSN: 1340-7988,1882-966X

DOI: 10.3918/jsicm.15.266